Benzylbenzoat

Produktnavn:

Benzyl benzoate

Synonyms:

N-tert-Butoxycarbonyl-L-aspartic Acid αBenzyl benzoate ReagentPlus(R), >=99.0%;Benzyl benzoate Vetec(TM) reagent grade, 98%;Benzoic acid benzyl ester≥ 99% (GC);VANZOATE(R);VENZONATE(R);Benylate;Benzyl alcohol benzoic ester

CAS:

120-51-4

MF:

C14H12O2

MW:

212.24

EINECS:

204-402-9

Produkt kategorier:

Løsemiddel; UORGANISKE OG ORGANISKE KJEMIKALIER; Kjemiske -; Aromatiske estere; Piperazin-derivater; organiske kjemiske stoffer; Byggesteiner; C12 til C63; Karbonylforbindelser; Kjemisk syntese; Estere; Ernæringsforskning; Organiske byggesteiner; Fytokjemikalier etter plante (mat / krydder / urt Vaccinium macrocarpon (Tranebær); CYSTADANE

Mol File:

120-51-4.mol

Smeltepunkt

18 °C

Boiling point 

323-324 °C(lit.)

density 

1.118 g/mL at 20 °C(lit.)

vapor pressure 

1 mm Hg ( 125 °C)

brytningsindeks

n20/D 1.568(lit.)

FEMA

2138 | BENZYL BENZOATE

FEMA

2797 | OCTANAL

Fp 

298 ° F

storage temp. 

2-8 ° C

solubility 

Miscible with ethanol, alcohol, chloroform, ether, oils.

form 

Væske

farge

Klar fargeløs

Water Solubility 

practically insoluble

JECFA-nummer

24

Merck

14,1127

BRN 

2049280

Stabilitet:

Stable. Substances to be avoided include strong oxidizing agents. Combustible.

InChIKey

SESFRYSPDFLNCH-UHFFFAOYSA-N

CAS DataBase Referanse

120-51-4 (CAS DataBase Reference)

NIST Chemistry Reference

Benzylbenzoat (120-51-4)

EPA Substance Registry System

Benzylbenzoat (120-51-4)

Hazard Codes 

Xn,N

Risk Statements 

22-51 / 53

Sikkerhetserklæringer

25-61-46

RIDADR

UN 3082 9 / PGIII

WGK Germany 

2

RTECS 

DG4200000

Selvantennelsestemperatur

896 °F

TSCA 

Ja

HazardClass

9

HS kode

29163100

Data om farlige stoffer

120-51-4(Hazardous Substances Data)

Toxicity

LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)

Beskrivelse

Benzylbenzoat (BnBzO) er et mediasjons- og insektmiddel. Det er en av de eldre preparatene som brukes til å behandle skabb, som er hudinfeksjoner forårsaket av tematisk scarcoptes scabiei, siden det er dødelig for midd. Den er i stand til å drepe midd på 5 minutter. Det kan også brukes til behandling av lusinfestasjon av hodet og kroppen. Virkningsmekanismen er å utøve giftig effekt på nervesystemet til insektene, noe som ytterligere forårsaker dens død. Det er også giftig å midd egg via en ukjent mekanisme. Den kan også brukes som et frastøtende middel for chiggers, flått og mygg, så vel som en fargestoffbærer, løsningsmiddel av cellulosederivater, myknere og et fiksativ.

Beskrivelse

Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.

Kjemiske egenskaper

Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor. It is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.

Kjemiske egenskaper

Colourless oily liquid with pleasant aromatic odour

Kjemiske egenskaper

Benzyl benzoate is a clear, colorless, oily liquid with a slightly aromatic odor. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃ it exists as clear, colorless crystals.

Kjemiske egenskaper

Benzyl benzoate has a light, balsamic odor reminiscent of almond and a sharp, pungent taste.

Bruker

benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.

Bruker

antiarteriosklerotisk, hypolipemisk, hepatoprotectant

Bruker

Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions.

Bruker

Used to kill lice and the mites responsible for the skin condition scabies.

Bruker

As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.

Production Methods

Benzyl benzoate is a constituent of Peru balsam and occurs naturally in certain plant species. Commercially, benzyl benzoate is produced synthetically by the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by the reaction of sodium benzylate with benzaldehyde.

Preparation

By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.

Merkenavn

Farmasøytisk nødvendighet for Dimercaprol [Injeksjon]. Benylate (Sterling Winthrop).

Taste threshold values

Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.

Hazard

Irritant to eyes, skin.

Kontakt allergener

Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.

Kjemisk syntese

This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.

Oppbevaring

Benzylbenzoat er stabilt når det oppbevares i tette, godt fylte, lett motstandsdyktige beholdere. Eksponering for overdreven varme (over 408â „ƒ) bør unngås.

Uforlikeligheter

Benzyl benzoate is incompatible with alkalis and oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Råvarer

Sodium -> Sodium carbonate -> Triethylamine -> Benzaldehyde -> Benzyl alcohol -> Benzoic acid -> Sodium benzoate -> Ethyl benzoate -> Peru balsam

Preparation Products

3-fenoksybenzylalkohol -> 2,6-dikloranilin -> 4-cyanofenol -> Batylalkohol -> Butetamin -> Disperse Yellow 126